Antifreeze reverses paralysis in dogs

Purdue scientists treated dogs who are paraplegic following trauma with a chemical cousin of antifreeze to repair spinal neurons. The results appear in December's Journal of Neurotrauma.

The neurons in the injured dogs were crushed from hemorrhaging rather than severed. The mechanism of action seems to be to stop cytoplasm from leaking out of the damaged cell's membrane. Purdue seeking approval for a similar trial in humans.

If polyethylene glycol helps spinal neurons, assuming it can be carried across the blood brain barrier, why not neurons in the brain? Perhaps it could be used to mitigate damage following a stroke.

Comments

[Garth Black]

Antifreeze is ethylene glycol. My wife used to work for a vet and animals like to drink it since it tastes sweet.

http://www.cah.com/library/antifreeze.html

[Arnab]

Hi,

I shall be eternaly grateful if somebody can provide information on cure / diagnosis / treatment of paralysis of a Labrador dog in his hind quarters.

I am from India and vetenary/pet treatment is not that very advanced. Any medical help that we can share with our doctors would help.

regards,
Arnab

[Mya de Pesántez]

Please write back to my e-mail if you have any ideas of treatment and any help for my shi-tzu dog . She has paralysis in her hind quarters.

[BRIAN TANN]

MY GREAT WHITE PEARINEASE SUDDENLY BECAME PARALIZED IN HIS "FRONT" LEGS
NOT HIND LEGS...
VET SAID HE WOULD OF DIED IF IT WAS ANTI-FREEZE. WE BROUGHT HIM HOME AND
HE CAN TRY TO GET UP ON HIS HIND LEGS BUT FRONT ARE LIKE SPAGHETTI.
ANY IDEAS?

[kelly Johnson]

hi my dogs name is Raphael and he was running to come in the house after we let him out to go to the bathroom, his front legs didn't make it up the first step and he went head first into the cement step, now he is sitting at the emergency vets office and he can't move his front legs, they believe that his brain cannot signal his front legs to move causeing him to have paralysis in his front legs, if you or anyone has any idea's please contact at this email because i have no idea how long he will last like this Thanks
Kelly

[Coral Mullaney]

Hi, I have a bloodhound named Elvis. One morning he couldn't use his left hind leg. The vet took x-rays and could not find anything wrong. If you have any thoughts you could share I would greatly appreciate it. Thank you.

[denise t]

my dog, a border collie, was paralyzed in his hind quarters. he started to improve very slowly until i took him for acupuncture. it really is helping and he is improving quicker. someone else i work with told me about it and takes her dog for acupuncture for his hind quarters as well. i only wish i had taken him right when it happened. the sooner the better.

[Rosemarie Lesniewski]

I have a 3 1/2 pound Yorkie. He is paralyzed in his front and hind legs. All his blood work is good. I aslo had a vet do acupuncture and an ajustment. But that was not helping. Please help.

[Jess Moore]

My dog is paralyzed and was diagnosed with Polyradiculoneuritis (Coonhound Paralysis).
Saliva from a raccoon can paralyze your dog by either eating the same food, biting, or scratching your dog. Most dogs fully recover but it can take up to 6 months. Mine has been paralyzed for 9 weeks. He goes to a water treadmill 3 times a week and gets electric stimulation in the legs as well.

[Catherine]

My 6yr old active wonderful little Maltesee, Isaiah is paralyized. Please please someone help me if you have a success treatment.

[Marlene Petri]

I have a 4 year old yorkie, he become paralized his back legs two years ago...he is moving his legs constantly now but can hold standing up for too long.
please help if you know some medicine or treatment. I live in California.
He waits to take him outside for an squeze every morning, he holds it...he seems happy but ....help

[Michelle]

HI i have a 3 year old doberman and this weekend he started shaking and his gradually has lost the use in his hind legs. we have taken him to the vets but they arent sure what is wrong with him and have just given him anti inflamatorys. He can't walk at all or have any use in his back legs please can someone give me some advise as i am really worried about him. thankyou

[Joyce]

i have an 8 year old large shepherd who was favoring his left hind leg for a week then loss use of both his hind legs. took him to vet who after several tests decided to do back surgery. he still cannot use his hind legs and we now have a cart for him. i am still hoping one day he will get his legs back.

[Susan]

My 7 yr. old Black Lab Sammy was suddenly weak in his front legs last week. He has some pain response but his leg condition overall is very weak. Xrays show severe arthritis in his elbows and minimal arthritis in his spine. My vet has checked thoroughly and there is no real explanation. He treated for Tick paralysis just to be safe, has ruled out cancer in the elbow, and possible embolism. He's only on Prednisone Acetate at this point. Any thoughts? I've been massaging him and he has regained some strength in his rear. I'm hoping he'll recover. I'd like to rehab him as soon as possible to avoid any more atrophy.

[steven davies]

My dog suffered from arthritis.A veterinarian friend told me to try with acupuncture,and it really helped.

[Crystal]

When i woke up today my dog was very weak in his legs and could not stand up if he did he would fall down right away..he has started shaking and i am very worred...is they any thing i could give him...and what should i do..can you please write me back right away..Thanks
Crystal

[kristen]

Our Maltese has hind quarter paralysis. What should we do for therapy, medication etc to get her up and moving again?

[michael jones]

Acupuncture is not something common! It is real miracle! I love it! It always helps me! Its benefits are countless!

[robin]

hi my 3 year daschund is suffering from paralysis as she got biten from another street dog ..!!i think its to the spinal cord whch she got biten.!!is threre anyhting reocvery from paralysis for my Dog.!!plzz do reply soon...!!
it is hard to see our dog lying liek dead...!!

[robin]

hi my 3 year daschund is suffering from paralysis as she got biten from another street dog ..!!i think its to the spinal cord whch she got biten.!!is threre anyhting reocvery from paralysis for my Dog.!!plzz do reply soon...!!
it is hard to see our dog lying liek dead...!!

[sicko]

My dog is a 2yr old Pit Bull/Mix im not sure how it happened but now all the sudden he is paralyzed from his front legs. Does someone know the procedure for Acupuncture since i see that its pretty much the best way for the dog to get better. If anyone can help that would be great i would really appreciate it. Like the lady above me said its hard to see my dog lying like if he is dead or dying its sad...

[Geeta]

On Wed. Jan 1st my almost 2yrs old lab came back from his usual morning run and had trouble puting his front left leg down, now its a week later and the front leg is Okay, i think. But now he has no strength in hind legs, he has trouble walking, climbing the sofa, it is as if he has lost all strength in his legs all of a sudden.

I dont understand why so many of us are see this, can anyone explain what is going on? and is acupuncture the best answer, has anyone else tried anything else.

Its really sad to see my dog not being able to do the simple things and he has just been lying around.

[Geeta]

On Wed. Jan 1st my almost 2yrs old lab came back from his usual morning run and had trouble puting his front left leg down, now its a week later and the front leg is Okay, i think. But now he has no strength in hind legs, he has trouble walking, climbing the sofa, it is as if he has lost all strength in his legs all of a sudden.

I dont understand why so many of us are see this, can anyone explain what is going on? and is acupuncture the best answer, has anyone else tried anything else.

Its really sad to see my dog not being able to do the simple things and he has just been lying around.

[Dan]

I have just sent an e-mail to a gentleman named Dr. Khouri regarding a treatment he
developed that has experienced some success.
It is called CP7. His e-mail is drk@dogparalysis.com. I will share his response.

[Larry]

I have a 9 month old lab. He underwent surgery on both hips for "Hip Dysplasia" and now his right hind leg has nerve damage. It is quite weak, but he still walks on it and puts weight on it. The problem is that he seems to have very little feeling in the lower part of the leg and walks on the top of his paw because it easily turns under when he walks.

The vet thinks he may have accidentially severed the sciatic nerve during the surgery. He said if his leg does not get anybody, we may have to consider ambutation! Obviously this will only be the last resort.

If anybody has had a similar experience and can tell me what they suggest I would really appreciate it!